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Multicenter Prospective Analysis of Treatment Outcome in Patients With Large Acoustic Neuromas
The investigators study is to investigate safety and efficacy of performing a planned incomplete removal of large acoustic neuroma tumors to decrease surgical morbidity and yet avoid tumor recurrence by post-operative radiation therapy.
The current standard treatment of a large tumor of the balance nerve (acoustic neuroma or vestibular schwannoma) is surgical resection. Complete removal of such tumor is associated with significant risks of hearing loss and facial paralysis whereas incomplete removal of the tumor is associated with significant risks of regrowth. Stereotactic radiation is a well accepted therapy aiming at stopping the growth of smaller acoustic neuromas before their sizes become large enough to cause problems. The purpose of our study is to determine whether the combination of subtotal resection followed by stereotactic radiation of the remnant can control large acoustic neuromas without the significant risks associated with complete resection.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Stanford University School of Medicine
Stanford, California, United States
George Washington University
Washington D.C., District of Columbia, United States
Indiana University
Indianapolis, Indiana, United States
University of Iowa
Iowa City, Iowa, United States
Louisiana State University
Baton Rouge, Louisiana, United States
Weill Cornell Medical College
New York, New York, United States
University of Cincinnati
Cincinnati, Ohio, United States
University of Texas Southwestern
Dallas, Texas, United States
Baylor College of Medicine
Houston, Texas, United States
Start Date
March 1, 2005
Primary Completion Date
May 8, 2022
Completion Date
May 8, 2022
Last Updated
May 10, 2022
157
ACTUAL participants
Microsurgery
PROCEDURE
Stereotactic radiation therapy
PROCEDURE
Lead Sponsor
Stanford University
Collaborators
Data Source & Attribution
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