Protandim and the Metabolic Syndrome

Exclusion Criteria

• •Women taking hormone replacement therapy for post menopause
• •Signs or symptoms of acute coronary syndrome
• •History of congestive heart failure (prior myocardial infarction, coronary artery disease including stent placement, coronary artery bypass graft, EBCT calcium score of at least 100, or a positive stress test)
• •Serum creatinine \> 1.5 mg/dL, AST or ALT \> 2 times ULN, HgA1c \>6.5%, severely depressed or elevated blood cell lines, triglycerides \> 500, TSH outside of normal range, elevated calcium, blood pressure \> 160/100, urine protein \> 30 ,g/dl.
• •Concurrent medical conditions/illnesses in which expected life expectancy is 2 years or less and/or are likely to require frequent hospitalizations and treatment adjustments (e.g., cirrhosis, active malignancy, , or highly active rheumatologic condition, lupus, rheumatoid arthritis or chronic obstructive pulmonary disease and diabetes).
• •Participation in any other investigational substance or medical device study within 30 days before this trial and/or participation in such entity during this trial.
• •Known pregnancy.
• •Supplementation with nutraceuticals or if so one month washout before initiating the study before initiating this trial.
• •Taking statins or fibrates to lower cholesterol
• •Inability or unwillingness to provide written informed consent