Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Recurrent or Progressive Glioblastoma

Inclusion Criteria

• •Patients must have histologically proven glioblastoma which is progressive or recurrent following radiation therapy +/- chemotherapy
• •Patients must have measurable contrast-enhancing progressive or recurrent glioblastoma by magnetic resonance imaging (MRI) imaging within two weeks of starting treatment; patient must be able to tolerate MRIs
• •GROUP B PATIENTS ONLY: Patients must be eligible for surgical resection according to the following criteria:
• •* Expectation that the surgeon can resect \>= 50% of the Gd-enhancing tumor with low risk of inducing neurological injury
• •* Absence of hematologic, cardiac or other medical contraindications to surgery
• •* Surgery must take place Monday-Thursday with the exception of patients being treated at Cleveland Clinic/University Hospitals: these patients may undergo surgery Monday-Friday
• •* Patients must have a tumor size \>= 2.5 cm in diameter in two perpendicular planes in order to enable correlative studies
• •* Paraffin embedded tissue must be available from initial surgical resection at diagnosis (prior to any treatment)
• •Patients may have an unlimited number of prior therapy regimens but no prior gamma-secretase inhibitors
• •Patients must have recovered from severe toxicity of prior therapy; the following intervals from previous treatments are required to be eligible:
• •* 3 months from the completion of radiation
• •* 6 weeks from a nitrosourea chemotherapy
• •* 3 weeks from a non-nitrosourea chemotherapy
• •* 4 weeks from any investigational (not Food and Drug Administration \[FDA\]-approved) agents
• •* 2 weeks from administration of a non-cytotoxic, FDA-approved agent (e.g., small molecule targeted therapy, thalidomide, bevacizumab, etc.)
• •Patients may not be on an enzyme-inducing anti-epileptic drug (EIAED); if previously on an EIAED, patient must be off for at least 14 days prior to the first dose of RO4929097
• •Patients must have a Karnofsky performance status \>= 60% (i.e. the patient must be able to care for himself/herself with occasional help from others)
• •Hemoglobin \>= 9 g/dL
• •Absolute neutrophil count \>= 1,500/mcL
• •Platelets \>= 100,000/mcL
• •Total bilirubin =\< institutional upper limit of normal
• •Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase \[SGOT\])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 4.0 x institutional upper limit of normal
• •Creatinine within institutional upper limit of normal OR
• •Creatinine clearance \>= 60 mL/min/1.73 m\^2 for patients with creatinine levels above institutional normal
• •Electrolytes - calcium, chloride, magnesium, potassium, phosphorus, sodium within institutional normal limits
• •Patients must be able to provide written informed consent
• •Women of childbearing potential and men must use two forms of contraception (i.e., barrier contraception and one other method of contraception) starting prior to study entry, for the duration of study participation, and for at least 12 months post-treatment; should a woman become pregnant or suspect she is pregnant while she or her partner are participating in this study and for 12 months after study participation, the patient should inform the treating physician immediately
• •* PREGNANCY TESTING: Women of childbearing potential are required to have a negative serum pregnancy test (with a sensitivity of at least 25 mIU/mL) within 10-14 days prior to treatment start and be required to agree to have the test repeated within 24 hours prior to the first dose of RO4929097 (serum or urine); a pregnancy test (serum or urine) will also be administered every 4 weeks (within 24 hours prior to starting every cycle) if their menstrual cycles are regular or every 2 weeks if their cycles are irregular while on study; a positive urine test must be confirmed by a serum pregnancy test; prior to dispensing RO4929097, the investigator must confirm and document the patient's use of two contraceptive methods, dates of negative pregnancy test, and confirm the patient's understanding of the potential of RO4929097 to cause serious or life-threatening birth defects
• •* Female patients of childbearing potential are defined as follows:
• •* Patients with regular menses
• •* Patients, after menarche with amenorrhea, irregular cycles, or using a contraceptive method that precludes withdrawal bleeding
• •* Women who have had tubal ligation
• •* Female patients may be considered to NOT be of childbearing potential for the following reasons:
• •* The patient has undergone total abdominal hysterectomy with bilateral salpingo-oophorectomy or bilateral oophorectomy
• •* The patient is medically confirmed to be menopausal (no menstrual period) for 24 consecutive months
• •Patients may not be breast-feeding
• •Patients must have no concurrent malignancy except curatively treated basal or squamous cell carcinoma of the skin or carcinoma in situ of the cervix, breast, or bladder; patients with prior malignancies must be disease-free for \>= five years
• •Patients must have a Mini Mental State Exam score of \>= 15