Cilengitide Together With Radiochemotherapy in Patients With Locally Advanced Non Small Cell Lung Cancer

Exclusion Criteria

• •1. Patients previously treated for a malignancy by means of chemotherapy, radiotherapy or surgery.
• •2. Uncontrolled hypertension
• •3. Uncontrolled bleeding within the last 3 months.
• •4. Patients under anti-coagulation with anti-vitamin K or therapeutic dose heparin ; low-molecular heparins for prophylaxis are permitted and are not considered an exclusion criterion.
• •5. Presence of cerebral metastases.
• •6. Participation in a clinical trial within the last 8 weeks.
• •7. Any other specific concomitant anti-tumor treatment (such as chemotherapy, radiotherapy …).
• •8. Patients with a history of myocardial infarction or a cerebral vascular accident within the last 12 months.
• •9. Continued use of aspirin (\>325mg/day)
• •10. Major surgery whiting the last 28 days or planned.
• •11. Major non-healing wound, ulcer
• •12. Pregnant or breastfeeding women cannot participate in this trial. Women of reproductive potential must have a negative pregnancy test (blood) within 72 hours before the start of treatment.
• •13. Men and women of reproductive potential must use an efficient contraceptive method when entering the trial and until one months after the end of treatment.
• •14. History of a thrombo-embolic or hemorrhagic event.
• •15. Patients put under tutelage.
• •16. Patients not able to follow the procedures visits, exams foreseen by the trial.
• •17. Any other severe medical or psychiatric condition or biological anomaly - acute or chronic - that, in the investigator's opinion - may render the inclusion of the patient inappropriate.