Medication and Counseling for Controlled Drinking

Exclusion Criteria

• •Current physical disease or condition making participant inappropriate for a medication trial, including total bilirubin elevation \>110% AST or ALT elevations \>300%
• •History of serious psychiatric illness (psychotic disorder, bipolar disorder, or psychiatric illness requiring hospitalization)
• •Recent (past three month) initiation of psychotropic medication or psychotherapy, or recent change in psychotropic medication treatment
• •Current DSM-IV diagnosis of drug (other than nicotine) dependence, or lifetime diagnosis of opioid dependence
• •DSM-IV alcohol dependence diagnosis judged clinically severe, history or present evidence of significant alcohol withdrawal symptoms, or recurrent use of alcohol to alleviate withdrawal
• •Regular use of opioids in the past month
• •History of of hypersensitivity to NTX
• •Considered by study physician not to be suitable for receipt of an investigational drug
• •Likely to require treatment with opiate pain medication during the course of the study