Corneal Collagen Crosslinking and Intacs for Keratoconus and Ectasia

Exclusion Criteria

• •Eyes classified as either normal, atypical normal, or keratoconus suspect on the severity grading scheme.
• •Corneal pachymetry ≤ 400 microns at the thinnest point measured by Pentacam in the eye(s) to be treated when the isotonic riboflavin solution is used or ≤ 300 microns when the hypotonic riboflavin us used, provided that the corneal thickness after treatment with the hypotonic riboflavin solution is \> 400 microns. Corneal pachymetry ≤ 450 microns at the proposed insertion site for the Intacs
• •Previous ocular condition (other than refractive error) in the eye(s) to be treated that may predispose the eye for future complications
• •History of corneal disease
• •History of chemical injury or delayed epithelial healing in the eye(s) to be treated.
• •Pregnancy (including plan to become pregnant) or lactation during the course of the study
• •A known sensitivity to study medications
• •Subjects with nystagmus or any other condition that would prevent a steady gaze during the CXL and Intacs treatment or other diagnostic tests.
• •Subjects with a current condition that, in the investigator's opinion, would interfere with or prolong epithelial healing.