Broccoli Sprout Extract in Treating Patients With Transitional Cell Bladder Cancer Undergoing Surgery

Exclusion Criteria

• •Have participated in any clinical trial involving conventional or investigational drugs or devices within the previous 4 weeks
• •Prior radiation to the pelvis
• •Intractable urinary tract infection that has not responded to antibiotic treatment
• •Active, uncontrolled bacterial, viral, or fungal infection including HIV
• •Have had major surgery within 4 weeks of starting therapy (not including placement of vascular access device or TURBT)
• •Poor medical risk in the opinion of the treating oncologist due to non-malignant systemic disease
• •Pregnant or lactating patients: patients must be postmenopausal or practicing an accepted form of birth control; for patients where pregnancy is a possibility, a pregnancy test will be required prior to initiation of therapy
• •Have a history of myocardial infarction or angina pectoris/angina equivalent in the last 6 months (the patient may be on anti-anginal medications if the symptoms have been entirely controlled for greater than 6 months), or have uncontrolled congestive heart failure
• •Have a history of bleeding disorders or thrombosis; patients on therapeutic doses of anticoagulation (including coumadin or heparins) are not permitted on trial (this exclusion criterion does not include those patients receiving low dose or prophylactic dose anticoagulation \[i.e. coumadin 1 mg daily in patients with central intravenous lines\])
• •Radiotherapy during the course of the trial
• •Inability to tolerate proposed treatment or procedures
• •Have additional uncontrolled serious medical conditions or psychiatric illness
• •Patients with a history of hepatitis (including but not exclusive to viral hepatitis auto-immune or alcoholic)
• •Patients with active thyroid disease (patients with hypothyroidism, adequately replaced on a stable dose of thyroid replacement will be allowed on trial)