Lead Sponsor

Bristol-Myers Squibb

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

No

•Males and females of childbearing potential (willing to use an acceptable method of contraception), or females of non-childbearing potential (i.e., post-menopausal or surgically sterile)
•Diagnosis of type 2 diabetes treated with metformin monotherapy on a stable regimen for at least 2 months
•Body Mass Index (BMI) of 18 to 40 kg/m2
•Fasting glucose in the range of 100-250 mg/dL
•Hemoglobin A1c (HbA1c) in the range of 6.5% -9.5%

•Clinically significant deviation from normal in medical history, physical examination, ECGs, and clinical laboratory determinations
•Any significant acute or chronic medical illness other than stable and well controlled hypertension, microalbuminuria, dyslipidemia, or depression
•Past history of diabetic ketoacidosis and/or C-peptide \< 1.0 ng/mL, hyperosmolar nonketotic syndrome, lactic acidosis, or recurrent hypoglycemia
•Any major surgery within 4 weeks of study drug administration
•Any gastrointestinal surgery that could impact upon the absorption of study drug
•Smoking more than 10 cigarettes per day
•Recent drug or alcohol abuse
•Women who are pregnant or breastfeeding
•Positive urine screen for drugs of abuse
•Positive blood screen for hepatitis C antibody, hepatitis B surface antigen, or HIV-1, -2 antibody