Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Vanderbilt University Medical Center
Age
40–85
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Hyperplastic polyp or/and Adenoma cases
Polyps free participants with any of the following high risk of colorectal polyps or cancer: (1) family history of colorectal cancer or polyps; (2) current cigarette smoker; (3) obesity (BMI≥30 kg/m2); (4) low intake of fiber (lowest fiber intake quartile: daily intake \<16.6g); (5) high intake of red meat and well-done or processed meat (mutageneity index ≥5852).
Participants from the TCPS (IRB # 090235), the TIARS (IRB # 090235), from Vanderbilt University Hospital or from other resources
Consent to be contacted for future studies in TCPS (IRB # 020462), TIARS (IRB#090235)
Participants with a calcium intake ≥ 700 mg/day measuring with 24 hour dietary recalls
Participants with a calcium intake \< 2000 mg/day measuring with 24 hour dietary recalls
Participants with a calcium/magnesium intake ratio \> 2.6
Participants with known genotype for Thr1482Ile polymorphism in TRPM7
Will live in Nashville or surrounding area in the next 6 months
You may not be if
Intolerance to magnesium glycinate or microcrystalline cellulose (placebo)
Chronic renal diseases and hepatic cirrhosis
Chronic ischemic heart disease with unstable angina, chronic heart failure at class III or IV and acute myocardial infarction in the last 6 months
Chronic diarrhea
Current breastfeeding
Current or planned pregnancy
Type I diabetes mellitus
Pituitary dwarfism
Use of digoxin and licorice
Current use of blood anticoagulant drugs such as Dicumarol(Warfarin), Clopidogrel (Plavix), Prasugrel HCl (Efficent), Ticlopidine (Ticlid), Lovenox (Enoxaparin), Fragmin (Dalteparin), Innohep (Tinzaparin), Eptifibatide (Integrilin), Tyrofiban (Aggrastat), and Abciximab (Reopro)
Current use of lithium carbonate therapy (Eskalith, Lithobid, Lithonate, Lithotabs, Apo-Lithium carbonate, Apo-Lithium carbonate SR, Carbolth, Duralith, PMS-Lithium carbonate, PMS-Lithium citrate)
Individuals with a history of colon resection or colectomy due to any reason
Individuals with any history of cancer other than non-melanoma skin cancer
Individual with history of any organ transplantation
Individual with a history of gastric bypass due to any reason
Individuals with Inflammatory bowel disease
Individuals if creatinine clearance is \< 50
Currently institutionalized
Homeless individual (address, telephone etc.)
Unable to provide informed consent
Any condition that in the opinion of the investigator raises concerns about protocol compliance
