Clareo Health | Preventive Effect of the PRetreatment With Intravenous Nicorandil on Contrast-Induced Nephropathy in Patients With RenaL Dysfunction UndEergoing Coronary Angiography (PRINCIPLE Study)
Preventive Effect of the PRetreatment With Intravenous Nicorandil on Contrast-Induced Nephropathy in Patients With RenaL Dysfunction UndEergoing Coronary Angiography (PRINCIPLE Study)
Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Yonsei University
With
GE Healthcare
Age
20–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients aged ≥ 20 years
Patients undergoing elective coronary angiogram due to documented myocardial ischemia or symptoms of angina
Estimated Cr clearance ≤60 mL/min by Cockcroft-Gault formula or serum Cr ≥1.1 mg/dL
Signed written informed consent to participate in the study
You may not be if
Acute myocardial infarction requiring primary or rescue coronary intervention
Allergic reaction to contrast dye or nicorandil
Cardiogenic shock or significant hypotension
Previous use of nicorandil within the preceding 7 days
Exposure to contrast medium within the preceding 7 days
Pregnancy or women at age of childbearing potential
Heart failure (NYHA class III or IV; LV ejection fraction \<40% by echocardiogram)
Acute renal failure or chronic dialysis
Mechanical ventilation
History of kidney transplantation
Life expectation less than 6 months
Previous renal artery angioplasty within the last 6 months
Use of nonsteroidal anti-inflammatory drugs, intravenous use of diuretics, dopamine, mannitol, N-acetylcysteine, ascorbic acid or sodium bicarbonate within 48 hrs before the procedure
