Catheter Ablation Versus Amiodarone for Shock Prophylaxis in Defibrillator Patients With Ventricular Tachycardia

Exclusion Criteria

• •Contraindication or allergy to contrast media, routine procedural medications or catheter materials
• •Contraindication to an interventional procedure
• •Current or previous (within 3 months) amiodarone therapy
• •Atrial Fibrillation requiring antiarrhythmic drug therapy
• •Contraindication to amiodarone therapy
• •New York Heart Association (NYHA) functional class IV
• •Myocardial infarction within the past 60 days
• •Stroke within the past 90 days
• •Unstable angina
• •Hypertrophic cardiomyopathy, Non-ischemic dilated cardiomyopathy, Arrhythmogenic Right Ventricular Dysplasia, Brugada Syndrome, Catecholamine sensitive polymorphic VT or long QT syndrome
• •Patients with active ischemia that are eligible for revascularization
• •Life expectancy less than 6 months
• •Incessant or multiple episodes of VT requiring immediate therapy with medications or ablation
• •Untreated hypothyroidism or hyperthyroidism. Patients who are euthyroid on thyroid hormone replacement therapy are acceptable.
• •Current enrollment in another investigational drug or device study.
• •Presence of any other condition that the investigator feels would be problematic or would restrict or limit the participation of the patient for the entire study period.
• •Absolute contra-indication to the use of heparin and or warfarin.
• •Documented intra-atrial thrombus, ventricular thrombus (\< 6 months after detection of thrombus), tumor, or another abnormality which precludes catheter introduction.
• •Females of childbearing potential who are not practicing protocol acceptable method of birth control.