Pilot Study of Safety and Efficacy of Sodium Phenylbutyrate in Spinocerebellar Ataxia Type 3

Exclusion Criteria

• •1. they show electrocardiogram ou echocardiographic alterations suggestive of heart insufficiency at baseline;
• •2. their serum creatinine levels are higher than 1.2 mg/dL, with the confirmation of renal insufficiency due to the rate of glomerular filtration;
• •3. they show a history of hypersensibility to sodium phenylbutyrate, and if
• •4. they (men and women) do not agree to use a reliable contraceptive method during the entire study period and for three months after its end.