Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Idorsia Pharmaceuticals Ltd.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. Signed informed consent prior to initiation of any study-mandated procedure
2. Male and female patients 18 years of age or older
3. Patients with PAH according to one of the following subgroups of the Dana Point Classification Group 1:
* Idiopathic, or
* Heritable, or
* Associated with connective tissue disease
4. Documented hemodynamic diagnosis of PAH by right heart catheterization (not part of study mandated procedures):
* Resting mean pulmonary arterial pressure (mPAP) ≥ 25 mmHg and
* Resting mean pulmonary vascular resistance (PVR) ≥ 240 dyn•s•cm 5 and
* Pulmonary capillary wedge pressure ≤ 15 mmHg
5. Modified NYHA functional class II-III
6. Patients on treatment with ERAs, PDE-5 inhibitors or a combination of both, if used for at least 3 months prior to Visit 1 and dosing kept stable for at least 28 days prior to Visit 1.
You may not be if
1. Patients with PAH in Dana Point Classification Groups 2-5, and PAH Group 1 subgroups not covered by inclusion criterion No. 3
2. Patients with sitting SBP \< 100 mmHg
3. Patients with sitting DBP \< 60 mmHg
4. Patients with body weight \< 50 kg (110 lbs)
5. Patients with clinically significantly elevated liver enzymes (AST, ALT and/or alkaline phosphatase \> 3 times upper limit)
7. Patients with moderate or severe hepatic impairment (Child-Pugh B and C)
8. Patients who have received prostacyclin (epoprostenol) or prostacyclin analogs (e.g., treprostinil, iloprost and beraprost) within 28 days of Visit 1
9. Patients who have received any investigational drugs within 28 days of Visit 1
10. Patients who have received cyclosporine A (CsA) or tacrolimus within 28 days of Visit 1
11. Psychotic, addictive or other disorder limiting the ability to provide informed consent or to comply with the study
12. Life expectancy less than 12 months
13. Females who are lactating or pregnant (positive pre-treatment pregnancy tests) (serum test at Screening and urine test on Visit 1 and 2) or females who are not using a reliable method of birth control (failure rate less than 1% per year) during the study and for at least one month after last administration of study drug
14. Known hypersensitivity to any of the excipients of the drug formulation.
