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COMPLETEDNCT01091805

Correlation of Oropharyngeal Pepsin and Gastroesophageal (GE) Reflux

The purpose of this research study is to see if GE reflux events are associated with increasing levels of pepsin in spit samples. Pepsin is a special protein called an "enzyme" that is made only in yo...

Lead sponsor: Wake Forest University Health Sciences•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Wake Forest University Health Sciences

Collaborators

Takeda

Age

All ages

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•1. Pediatric patients from birth to 18 years (including premature infants) who are deemed clinically to require 24 hour esophageal pH/impedance.
•2. Pediatric patients (newborn to 18 years) undergoing MBS who have had or will have pH/MII monitoring within 6 months.
•3. Patients' parents or legal guardians will provide written informed consent for the protocol. When appropriate, patient assent will be obtained.

Exclusion Criteria

•1. Patients with anatomic facial anomalies or facial discomfort precluding nasal intubation of the pH/MII catheter.
•2. Patient unable to complete a 24 hour pH/MII study.
•3. Children fed exclusively with nasogastric or nasojejunal (transpyloric) tube at the time of study.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: April 13, 2017Terms

Trial snapshot

StatusCOMPLETED

Phase—

Enrollment143

Start dateDec 2008

Last updatedApr 13, 2017

Condition

Gastroesophageal Reflux Disease (GERD)

Locations shown

Wake Forest University Baptist Medical Center

Winston-Salem, North Carolina

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 13, 2017Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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