Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Pamlab, Inc.
With
Massachusetts General Hospital
Blood levels of L-methylfolate and biological activity will be evaluated by examining changes in plasma homocysteine concentrations, serum methionine concentrations and changes in brain activation as measured by fMRI.
Age
18–68
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Diagnosis of schizophrenia, any subtype
Male of female
Age 18-68 years
Treated with an antipsychotic for at least 6 months at a stable dose for at least 6 weeks
PANSS total score of at least 60, with at least 3 (moderate) on one negative symptom item or on one positive symptom item
Simpson Angus Scale (SAS) for the EPS total score of 12 or less and
A score of 2 (mild) or less on all items of the Calgary Depression Rating Scale (CDRS)
Comprehension of English adequate to complete cognitive testing
You may not be if
Unable to provide informed consent
CBC results consistent with megaloblastic anemia
Serum creatinine concentration greater than 1.4
Current use of folate supplementation \> 400mcg folate
Alcohol or other substance abuse within 3 months (nicotine allowed)
Current use of any of the following medications: phenobarbital, phenytoin, carbamazepine, valproic acid, fosphenytoin, primidone or pyrimethamine
Positive baseline urine toxic screen, (positive test for PCP, barbiturates, cannabinoids, amphetamines, benzodiazepines, opiates, or cocaine)
Unstable medical illness (exclusionary lab values are listed in Appendix A)
Unstable psychiatric illness
Seizure disorder
Pregnant or nursing, or planning/trying to get pregnant within the next 6 months, and
DSM-IV diagnosis of major depressive disorder
Clareo Health | A Placebo-Controlled Study of Physiologic Effects of L-methylfolate in Schizophrenia Patients
