Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of California, Los Angeles
With
National Institute of Mental Health (NIMH)
Age
62–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
62 years of age or older
Meet the DSM-IV diagnosis of MDD based on Sheehan's Mini-International Neuropsychiatric Interview (MINI), with a score of \> 28 on the 30-item Inventory of Depressive Symptomatology - Self Rated version (IDS-SR30)
You may not be if
Subjects will have no unstable medical illness that would prevent completion of participation in the trial, determined as needed from physical examination, ECG, laboratory safety tests, as well as a review of systems
mentally or legally incapacitated, unable to give informed consent
meets DSM-IV criteria for anorexia nervosa, bulimia nervosa, obsessive-compulsive disorder, any cognitive disorder, bipolar disorder, psychotic disorder, or major depression with psychotic features
MMSE (Folstein et al., 1975) score ≤ 24
evidence of drug dependency or substance abuse within the preceding nine months
stable and in remission on current psychotropic medication(s)
any ECT within the past six months
failure to tolerate ESC or treatment failure with an adequate trial of ESC in the current episode
ESC would be contraindicated (e.g., hyponatremia with a prior SSRI)
treatment with fluoxetine or an MAOI within the past four weeks
any medical illness severe enough to significantly affect brain function or to interfere with interpretation of study results
history of seizures, brain surgery, skull fracture, significant head trauma, or abnormal EEG
psychiatric hospitalization indicated (e.g., imminent danger to self or others)
initial QEEG recording is contaminated with artifact so that determination of the biomarker is precluded
use of medications known to affect brain function (e.g., antidepressants, anticonvulsants/mood stabilizers, anticholinergics, antipsychotics, benzodiazepines - same list as in BRITE-MD)
Clareo Health | Biomarkers for Outcomes In Late-life Depression (BOLD)
