Radiation Therapy in Treating Women With Locally Recurrent Breast Cancer Previously Treated With Repeat Breast-Preserving Surgery

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically confirmed locally recurrent breast carcinoma consistent with the following cell types:
• * Invasive ductal breast carcinoma
• * Medullary ductal breast carcinoma
• * Tubular ductal breast carcinoma
• * Mucinous ductal breast carcinoma
• * Lobular breast carcinoma
• * Ductal carcinoma in situ (DCIS)
• * No Paget disease of the nipple
• * Target lumpectomy cavity must be clearly defined and the target lumpectomy cavity/ whole-breast reference volume must be \< 30% based on a post-operative, pre-treatment CT scan
• * Tumor size ≤ 3 cm in greatest dimension on pathologic specimen
• * Negative histologic margins of resection and no tumor on ink following breast-preserving surgery of local recurrence (Re-excision is permitted to achieve negative margins)
• * Axilla negative or ≤ 3 positive lymph nodes without extracapsular extension
• * If the in-breast recurrence is DCIS and/or microinvasive disease, a sentinel lymph node (SLN) evaluation is not required, but if performed:
• * Patients with a negative sentinal lymph node (SLN) biopsy are eligible for enrollment
• * Patients with a positive SLN biopsy require an axillary lymph node (ALN) dissection (ALND is not required if the SLN is not identified)
• If the in-breast recurrence is invasive disease and:
• * No prior ALN dissection or SLN dissection only:
• * Patient is required to undergo axillary evaluation with either a SLN or ALN dissection
• * If the SLN is not identified or if the SLN is positive for metastatic disease then an ALN dissection is required
• * Patient is eligible for enrollment if encounter 0-3 positive lymph nodes without extracapsular extension
• * • Prior ALN dissection: negative clinical exam: patient is eligible for enrollment
• * It is recommended, but not required, that the patient undergo ultrasound evaluation of the axilla and the lymph node draining regions of the breast; any suspicious areas are to be biopsied and if positive followed with an ALN dissection
• * Patient is eligible for enrollment if biopsies are negative or 0-3 axillary lymph nodes without extracapsular extension are encountered
• * Prior ALN dissection: positive clinical exam: biopsy required
• * If biopsy is negative, patient is eligible for enrollment
• * If biopsy is positive an ALN dissection is required
• * Patient is eligible for enrollment if biopsies are negative or 0-3 axillary lymph nodes without extracapsular extension encountered
• Ipsilateral breast mammogram and MRI within 120 days prior to study entry
• Contralateral breast mammogram within 12 months of study entry
• For invasive in-breast recurrence, no more than 120 days since whole-body (positron emission tomography) PET-CT scan OR CT scan of the chest, abdomen, and pelvis, and bone scan
• No multicentric ipsilateral breast recurrence or regional recurrence (other than axilla)
• Patients must have a breast technically amenable to partial-breast irradiation
• No metastatic disease documented by physical exam or radiographic evaluation (for patients with invasive disease)
• No skin involvement
• No prior contralateral mastectomy
• Estrogen and progesterone status must be known
• PATIENT CHARACTERISTICS:
• Zubrod performance status 0-1
• Menopausal status not specified
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• No other invasive malignancy within the past 3 years except ipsilateral breast cancer and/or nonmelanoma skin cancer
• No collagenous diseases, specifically systemic lupus erythematosus, scleroderma, or dermatomyositis
• No psychiatric or addictive disorders that would preclude obtaining informed consent
• PRIOR CONCURRENT THERAPY:
• See Disease Characteristics
• More than 2 weeks since prior chemotherapy and recovered
• No concurrent intensity-modulated radiotherapy
• No concurrent chemotherapeutic agents, including trastuzumab