Clinical diagnosis of current alcohol or sedative dependence, bipolar disorder; or a life-time diagnosis of anorexia nervosa or bulimia

Seeking/receiving treatment for opiate-agonist replacement therapy

Medical conditions that could compromise participant safety

Taking medications with known/potential interactions with bupropion

Hypersensitivity to bupropion, nicotine, or menthol

Pregnant or breastfeeding

Abnormal ECG

Recent smoking cessation treatment

Use of tobacco products other than cigarettes in the past week

Likely to enter residential/inpatient treatment within 10 weeks

Have all stimulant-positive urine drug screens during screening/baseline

Smoking-Cessation and Stimulant Treatment (S-CAST)