Recovery Time in Children With Lower Respiratory Tract Infections Treated With Klacid® Granules for Oral Suspension.

Exclusion Criteria

• •Known hypersensitivity to or previously intolerant of macrolides.
• •Illness severe enough to warrant hospitalization or parenteral therapy.
• •Concomitant use of any of the following medications:
• •* Drugs metabolized by CYP3A isozyme: alprazolam, astemizole, carbamazepine, cilostazol, cisapride, cyclosporin, disopyramide, ergot alkaloids, lovastatin, methylprednisolone, midazolam, omeprazole, oral anticoagulants (e.g. warfarin), pimozide, quinidine, rifabutin, sildenafil, simvastatin, tacrolimus, terfenadine, triazolam and vinblastine.
• •* Drugs metabolized by other isozymes within CYP450 system: phenytoin, theophylline and valproate.
• •* Colchicine
• •* Digoxin
• •* Ritonavir.
• •Severe immunodeficiency and chronic disease conditions.
• •Renal or hepatic impairment.