Study on Cognitive Disorders of Multiple Sclerosis

Exclusion Criteria

• •Progressive form MS
• •MS relapse of less of 4 weeks.
• •IV or oral corticoid treatment in the month preceding the screening
• •Medicinal treatments or non medicinal in cognitive or psychology-stimulant aim in the 3 months before the screening
• •Tumoral form MS visible in the MRI.
• •Depressive syndrome (MADRS score \> 19).
• •Quite other diagnosed psychiatric pathology
• •Known allergy or quite contraindication in memantin : renal or hepatic insufficiency, turned out epileptic disease, treatment by ketamine, amantadin, dextromethorphan, L-Dopa, dopaminergic agonist, barbituric, neuroleptic, 3,4-diaminopyridine, lithium, cimetidine, ranitidine, procainamide, quinine, nicotine, hydrochlorthiazide and ally, phenytoin, modafinil.
• •Recent treatment (less of 4 weeks) by antidepressants and/or anxiolytics.
• •Pregnancy or feeding.
• •Minor or Major "protected by the law" patient
• •Uncontrolled diet.
• •Patient having benefited of one psychometric assessment(including in particular tests planned in the protocol) since less of one year.