Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University Hospital, Caen
With
Ministry of Health, France
H. Lundbeck A/S
Age
18–60
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Remitting Multiple Sclerosis defined by Mc Donald et al., 2001
Patient with authorised immunomodulator treatment or oral immunosuppressive therapy during more than three months: Bétâ Interferon, glatiramer acetate, azathioprine, methotrexate, mycophenolate mofetil, treatment by monoclonal antibody I.V. or anti-VLA4, natalizumab (Tysabri)
Patient having benefited, possibly, of following treatments : mitoxantrone, cyclophosphamide, cyclosporine, general-purpose immunoglobulins, only if the treatment is ended more of 6 months before the inclusion.
EDSS score ≤ 5.5
DRS score ≥ 130
PASAT 3s score \> 15 and \< median / control subjects according to 2 age brackets, sex, school level.
Signed the informed consent form.
Effective contraception for women in age to procreate
You may not be if
Progressive form MS
MS relapse of less of 4 weeks.
IV or oral corticoid treatment in the month preceding the screening
Medicinal treatments or non medicinal in cognitive or psychology-stimulant aim in the 3 months before the screening
Tumoral form MS visible in the MRI.
Depressive syndrome (MADRS score \> 19).
Quite other diagnosed psychiatric pathology
Known allergy or quite contraindication in memantin : renal or hepatic insufficiency, turned out epileptic disease, treatment by ketamine, amantadin, dextromethorphan, L-Dopa, dopaminergic agonist, barbituric, neuroleptic, 3,4-diaminopyridine, lithium, cimetidine, ranitidine, procainamide, quinine, nicotine, hydrochlorthiazide and ally, phenytoin, modafinil.
Recent treatment (less of 4 weeks) by antidepressants and/or anxiolytics.
Pregnancy or feeding.
Minor or Major "protected by the law" patient
Uncontrolled diet.
Patient having benefited of one psychometric assessment(including in particular tests planned in the protocol) since less of one year.
