Empiric Therapy of Mucopurulent Cervicitis (MPC)

Exclusion Criteria

• •Signs and symptoms of pelvic inflammatory disease, including cervical motion, uterine, or adnexal tenderness.
• •History of pelvic inflammatory disease (PID), ectopic pregnancy or recurrent cervicitis (3 or more episodes in the prior year) or written documentation of recent cervicitis (within past 30 days).
• •Gonorrhea or Chlamydia on nucleic acid amplification test (NAAT) at time of enrollment. (Participant testing positive for Neisseria gonorrhoeae (GC) or Chlamydia trachomatis (CT) on enrollment visit sample will be discontinued).
• •Women with motile trichomonas on wet mount examination or positive trichomonas culture at time of enrollment.
• •Women with symptomatic bacterial vaginosis (BV) (based on clinical Amsel criteria for BV and reported symptoms by participant, i.e. discharge, vaginal odor, etc).
• •Use of vaginal products in past 48 hours (i.e. douching, use of vaginal medications or suppositories).
• •History of chronic renal disease by verbal or documented history.
• •Current use of probenecid.
• •Nursing mothers.
• •Colitis or coagulopathy as per patient self-report.
• •Known allergy to cephalosporins, penicillin or macrolides by verbal or documented history.
• •History of latex allergy.
• •Use of systemic antibiotics (oral or intravenous), vaginal antibiotics, vaginal antifungal, or oral antifungal use within 30 days of study enrollment.
• •Women who will require antibiotic treatment due to GC or CT in a sexual partner.
• •Serious underlying conditions, including human immunodeficiency virus (HIV) or other primary or secondary immunosuppressive condition.
• •Concomitant infection, which requires antimicrobial therapy (for example, urinary tract infection, sinusitis, skin and soft tissue infection, tooth abscess, etc.) or expected use of any antibiotic/antimicrobial therapy during the study.
• •Menstruation at the time of screening visit. Women who are menstruating can be screened after cessation of bleeding.
• •Active herpes outbreak at the time of enrollment determined by clinical observation.
• •Suspected pregnancy or positive urine pregnancy test at screening or actively seeking pregnancy during study period.
• •Any clinical adverse event, intercurrent illness, or other medical condition or situation as determined by the investigator that is present or occurs such that participation in the study would not be in the best interest of the participant.
• •Previously enrolled in this study.
• •Unable to follow the protocol (inc. inability to comply with the follow-up procedures).
• •Failing to provide contact information.