Lead Sponsor

XOMA (US) LLC

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

No

•Diagnosed with T2D (disease duration ≥ 6 months)
•HbA1c ≥ 6.8% and ≤ 10.0%
•Have been on a stable regimen of metformin monotherapy for at least 12 weeks prior to Day 0
•Willingness to maintain stable diet and exercise regime throughout the study
•Willingness to maintain current doses/regimens of vitamins and dietary supplements through the end of the study

•Uncontrolled hypertension
•History of malignancy within 5 years
•History of allergic or anaphylactic reactions to humanized or murine monoclonal antibodies
•Advanced stage heart failure (New York Heart Association \[NYHA\] class 3 or 4)
•Clinically significant uncontrolled arrhythmias
•History of tuberculosis
•Active leg, foot, or decubitus ulcer
•Any significant inflammatory, rheumatologic, or systemic autoimmune disease
•History of chronic infections
•History or any symptoms of a demyelinating disease
•Major surgery within 3 months
•Female subjects who are pregnant, planning to become pregnant