Pangenomic Study During Alcoholic Cirrhosis

Genetical Predisposition in Hepatocellular Carcinoma : Pangenomic Link Study During Alcoholic Cirrhosis

NCT01065233•Nantes University Hospital

Summary

Hepatocellular carcinoma (HCC) is a frequent complication of cirrhosis. Occurrence of HCC could be linked with multiple functional region of genome. The determining of a genomic mapping of " single nucleotide polymorphisms " (SNPs) permit to perform some genetic link studies with pathologies without clear hereditary disposition. In this study, the investigators will identify predictives genetic polymorphism of HCC.

Eligibility

Age

35 - 70 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•35 to 70 years old
•Compensated cirrhosis or not
•Caucasian origin of the parents
•Patient with cirrhosis (histological proof or obvious)

Exclusion Criteria

•HIV, HBV, HCV positive
•Known Homozygotia (C282Y+/+)
•Important hepatocytary iron overload for patient with resection
•HCC non histologically prooved

Locations (4)

Nantes UH

Nantes, France

Jean Verdier UH

Paris, France

Paul Brousse UH

Paris, France

Rennes UH

Rennes, France

Key Dates

Start Date

October 23, 2008

Primary Completion Date

December 27, 2011

Completion Date

July 20, 2013

Last Updated

September 17, 2021

Enrollment

1,325

ACTUAL participants

Conditions

Alcoholic Cirrhosis

Interventions

DNA extraction

GENETIC

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TERMINATEDPHASE3

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 17, 2021Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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