Safety Study of a Single IVT Injection of QPI-1007 in Chronic Optic Nerve Atrophy and Recent Onset NAION Patients

Exclusion Criteria

• •For the study eye only: history of any IVT injection or vitrectomy, vitreous hemorrhage, retinal detachment, or active inflammatory condition (e.g. conjunctivitis).
• •For either eye: history of uveitis.
• •Enrollment is now closed in Stratum I.
• •For the study eye only: Macular disease, retinopathy, or other eye disease limiting visual acuity; prior intraocular surgery (other than Lasik) and cataract surgery within 3 months prior to dosing; glaucoma laser surgery within 1 month prior to dosing; pain on or aggravated by eye movement; history of vitreous hemorrhage; history of retinal detachment; any active inflammatory condition (e.g. conjunctivitis); glaucoma or ocular hypertension; or intraocular pressure \> 26 mmHg.
• •For either eye: History of optic neuritis; or history of uveitis.
• •Received any treatment for NAION prior to dosing.
• •Any other abnormality which in the opinion of the investigator is suggestive of a disease other than NAION in the study eye only.
• •Clinical evidence of temporal arteritis.
• •History of collagen vascular disease or other inflammatory disease, or history of multiple sclerosis.
• •Enrollment in Stratum II is still open.