The Adrenal Contribution to Androgen Production in Girls During Puberty

Exclusion Criteria

• •Pregnancy
• •On oral contraceptives
• •On insulin lowering drugs
• •On anti-androgens (i.e., spironolactone, flutamide, finasteride, etc)
• •On medications that will influence androgen metabolism or clearance
• •On medications that will inhibit the cytochrome P450 enzyme system (cimetidine, ketoconazole, etc)
• •Subjects with morning cortisol\<5 ug/dL will be excluded and asked to see their primary care physician.
• •Subjects with 17-OHP\>250 ng/dL) will be excluded and asked to see their primary care physician.
• •Subject with a history of Cushing syndrome or adrenal insufficiency will be excluded