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Dose Response Relationship of Dexmedetomidine in Decreasing Post Operative Analgesic Requirements in the Pediatric Tonsillectomy Patient
The hypothesis of this study is that the administration of an intra-operative dose of dexmedetomidine will result in adequate analgesia without respiratory depression thereby resulting in an early discharge from the post anesthetic care unit following adenotonsillectomy.
Dexmedetomidine, an alpha 2 agonist provides some analgesia without respiratory depression. Children undergoing tonsillectomy and adenoidectomy occasionally have episodes of respiratory obstruction in the recovery room following administration of opioids. As dexmedetomidine provides some analgesia without respiratory depression,an intra-operative dose of dexmedetomidine may provide adequate analgesia without significant side effects thereby allowing for quick post operative recovery.
Age
3 - 17 years
Sex
ALL
Healthy Volunteers
Yes
Texas Children's Hospital, Baylor College of Medicine
Houston, Texas, United States
Start Date
August 1, 2005
Primary Completion Date
November 1, 2010
Completion Date
December 1, 2010
Last Updated
July 27, 2021
109
ACTUAL participants
Dexmedetomidine 0.75 mcg/kg
DRUG
Morphine 50 mcg/kg
DRUG
Morphine 100 mcg/kg
DRUG
Dexmedetomidine 1 mcg/kg
DRUG
Lead Sponsor
Baylor College of Medicine
NCT07388953
NCT07221682
Data Source & Attribution
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