Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Oxagen Ltd
With
Medicines Evaluation Unit, Manchester, UK
King's College Hospital NHS Trust
Age
18–45
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Known history of asthma (intermittent wheezing, cough, dyspnoea responsive to inhaled short acting beta agonists).
FEV1 \>65% of predicted on at least two occasions at screening.
At the screening allergen challenge, a decrease in FEV1 of ≥20% in the early asthmatic reaction and of ≥15% in the LAR to allergen on 3 separate occasions between 3-10hrs post allergen, 2 of which must be consecutive.
No steroid usage in the past 12 weeks.
Testing positive to skin prick challenge with at least one of the following allergens: house dust mite, pollen or cat hair within the previous 12 months.
Non smokers for a minimum of 6 months; less than 10 pack year history.
You may not be if
Respiratory tract pathology other than allergic asthma.
Lower respiratory tract infection within 4 weeks prior to an allergen challenge.
Receipt of prescribed or OTC medication other than paracetamol or short acting inhaled beta agonists within 14 days of screening or of the first day of each dosing period.
Clareo Health | OC000459 Bronchial Allergen Challenge
