Long-Term Study of Multi-target Therapy as Maintenance Treatment for Lupus Nephritis

Inclusion Criteria

• •1. Patients who signed written informed consent form
• •2. SLE patient, aged between 18-65 years, female or male;
• •3. Patients diagnosed lupus nephritis according to ISN/RPS 2003 classification criteria, class Ⅲ, Ⅳ,Ⅳ+Ⅴ, Ⅲ+Ⅴ or Ⅴ LN by renal biopsy
• •4. All patients had received induction therapy for 6 months with multi-therapy (FK506 + MMF) or intravenous CTX pulses.
• •5. Patients were recruited when received partial remission or complete remission after 6 months induction therapy.
• •Complete remission: proteinuria \<0.4 g/24h, negative urine sediment, serum albumin \>35 g/L, elevated scr \<0.3mg/dl, no extra-renal complications; Partial remission: proteinuria \<1.0 g/24h, urine RBC \<50X104/ml without casts, serum albumin \> 30 g/L, elevated Scr \<0.3mg/dl,no extra-renal complications.