Safety Study of a Single Dose of REGN88(SAR153191)in Patients With Rheumatoid Arthritis

Exclusion Criteria

• •1. A history of Listeriosis or active tuberculosis (TB)
• •2. Persistent chronic or active recurring infection requiring treatment with antibiotics, antivirals, or antifungals within 4 weeks prior to the Screening Visit
• •3. History of prior articular or prosthetic joint infection
• •4. History of a hypersensitivity reaction, other than localized injection site reaction (ISR), to any biological molecule
• •5. Significant concomitant illness such as, but not limited to cardiac, renal, neurological, endocrinological, metabolic or lymphatic disease that would adversely affect the subject's participation in this study
• •6. Received administration of any live (attenuated) vaccine within 3 months prior to the Screening Visit