Lead Sponsor

Nantes University Hospital

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

No

•For IBD: Clinically and histologically proven UC and Crohn's disease involving at least 30% of colon, with disease duration over 8 years for pancolitis or over 15 years for left colitis
•For FAP: patients at least 2 years after colectomy, with either rectal stump or ileal pouch
•Obtained signed informed consent

•\- For IBD: Active disease (only for cohort I a) : For UC: Colitis Activity index \>= 8, Truelove and Witt's activity index: moderate or severe For CD: CDAI: \> 150
•Known intraepithelial neoplasia or colorectal cancer or any other malignancy
•Coagulopathy
•Prothrombin time \< 50% of control
•Platelet blood count \< 70 000/mm²
•Impaired renal function (creatinine \> 1.2 mg/dl)
•Pregnancy or breast-feeding
•Known allergy to indigo-carmin or fluorescein