Phase 1 Study to Evaluate RDC-0313 Coadministered With Buprenorphine to Opioid-Experienced Healthy Adults

Inclusion Criteria

• •Subject must be capable of understanding and complying with the protocol and has signed the informed consent
• •Must be 18-55 years of age
• •Must have a body mass index of 18.0-30.0 kg/m2 at screening
• •Female subjects must agree to use an acceptable method of contraception from date of consent and until two weeks after the last dose
• •Subjects must be willing not to use alcohol-, tobacco, caffeine-, or xanthine-containing products while resident at inpatient facility
• •Subjects must be an experienced opioid user who meets the following criteria: 1) has used opioids for non-therapeutic purposes (ie, for psychoactive effects) on at least 10 occasions in the past five years; 2) has used opioids at least 2 times in the two years prior to screening; and 3) is not physically dependent on opioids, as assessed by medical history and naloxone challenge performed at screening