Subjects with stable type 1 diabetes mellitus on multiple daily insulin injections including basal and bolus will be selected in order to determine the correct insulin dosing formulas. Subjects will be placed on continuous glucose sensor (CGMS) and an isocaloric diet. Subjects will have the CGMS downloaded daily and the insulin doses adjusted if necessary. Subject will do four SMBGs daily to calibrate CGMS and on last day a 7-point SMBG. subjects will be on lispro and glargine insulin. Basal insulin will be once a day.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age: \>17 years
Type 1 diabetes
Diabetes duration \> 3 months
On treatment with multiple daily injections either one or more basal insulin injections each day for 6 weeks
HbA1c \<9.0%
Stable HbA1c in the proceeding 3 months (i.e., change \<1%)
Demonstrated adherence to visits and instructions
Attend a class in meal carbohydrate content estimation or have demonstrated knowledge of carbohydrate counting
You may not be if
Major stress event during or for 6 weeks before the evaluation
Taking a medication that can alter insulin sensitivity
Within one week of menses
Unstable eating or activity pattern
Pregnancy
Weight gain of \> 1.5 kg during the preceding 3 months
Serum creatinine of \>1.5 mg/dl
Active liver disease
Evidence of autonomic neuropathy, especially gastroparesis
Any antidiabetic medication other than insulin
Treatment with continuous subcutaneous insulin infusion
Clareo Health | A Study of the Rules for Insulin Dosing in Patients Using Multiple Daily Injections
