Cyclobenzaprine Extended Release (ER) for Fibromyalgia

Exclusion Criteria

• •Be pregnant or be attempting to conceive at present (urine bHCG must be negative)
• •Have an active substance abuse problem with last use within the past 90 days (outside of nicotine)
• •Use cardiac QTc prolonging medications i.e., tricyclic antidepressants
• •Use p4502D6 major inhibiting medications as cyclobenzaprine levels may increase
• •Have a known medical condition outside of FM that causes pain, i.e., diabetic neuropathy
• •Have a known medical condition or other medication use that relatively contraindicates cyclobenzaprine use (i.e., hypersensitivity concomitant use of monoamine oxidase (MAO) inhibitors, seizures, known cardiac abnormalities, recent MI. hepatitis, stroke, or psychosis
• •Has a prior history of cyclobenzaprine use and failure (failure due to side effects may be allowed at P.I. discretion)
• •Be receiving daytime/nighttime sedating medication with clear chronological impact on fatigue UNLESS fatigue predates sedating medication or said medication has been steadily dosed \> 4 weeks
• •Other medications known to alleviate pain (i.e., Gabapentin, Pregabalin, Amitryptiline, Duloxetine,Venlafaxine, Carbamazepine, Tramadol, etc) unless they have been at steady dose more than 6 weeks