Calcitriol in Advanced Intrahepatic Cholangiocarcinoma

Inclusion Criteria

• •1. Proven histological or cytological diagnosis of advanced intrahepatic cholangiocarcinoma (stage III, IV); Patients are ineligible for surgery.
• •2. Patients must have measurable or evaluable disease.
• •3. Age between 30-65 years
• •4. Performance status must be ECOG 0-1.
• •5. No prior use of chemotherapy or palliative radiation
• •6. Tumor size by CT scan must be larger than 10 mm.x10 mm.
• •7. Life expectancy of at least 12 weeks.
• •8. Adequate bone marrow, hepatic, and renal function, as evidenced by the following: WBC \> 3.0 x 109/L, neutrophils \> 1.5 x 109 /L; platelet count \> 100 x 109/L; Hct \> 30%; total bilirubin \< 1 mg/dL; Liver enzymes (alkaline phosphatase, AST, ALT) \< 3 times the upper limit of the normal range. Creatinine within the normal range.
• •9. Female patients must not be pregnant; they must be post-menopausal or practicing an accepted form of birth control. If pregnancy is a possibility, a pregnancy test will be required prior to initiation of therapy.
• •10. Patients must be accessible for treatment and follow-up.
• •11. Patient and investigator signed study-specific consent form, indicating the investigational nature of the study.