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The soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) was an established biomarker useful for infection in non-neutropenic patients. In this study, we tested sTREM-1 in the patients with neutropenic fever. Pro-calcitonin (PCT) and C-reactive protein (CRP) were also measured. We planned to investigate and explore the role of sTREM-1 in early diagnosis of infection in patients with neutropenic fever.
Patients with hematological malignancies developed neutropenia after chemotherapy. We checked the serum level of sTREM-1 in patients with neutropenic fever. Those patients were classified to 2 groups: documented infection or low likelihood of infection. Their sTREM-1 level was measured and was compared with other biomarker such as CRP and procalcitonin. The value of sTREM-1 for diagnosis of infection in patients with neutropenic fever was thus evaluated.
Age
18 - 84 years
Sex
ALL
Healthy Volunteers
No
Start Date
October 1, 2008
Primary Completion Date
June 1, 2009
Completion Date
June 1, 2009
Last Updated
December 17, 2009
75
ACTUAL participants
Lead Sponsor
National Taiwan University Hospital
NCT07016165
NCT06977490
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