Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Aristotle University Of Thessaloniki
Age
40–85
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1st part of the study:
* COPD clinically stable (patients with post-bronchodilation FEV1/FVC \<0.7 and no acute exacerbations, hospital admissions or treatment changes in the last 3 months).
* 2nd and 3rd part:
* As above.
You may not be if
1st part of the study:
* history of asthma,
* history of respiratory infection in the last 3 months
2nd and 3rd part: As above and additionally:
* history of malignancy or haematologic disorder
* acute or chronic inflammatory disease
* systematic or autoimmune disorder
* thyroid disease
* liver cirrhosis
* heart failure (ejection fraction \<55%)
* history of gastrointestinal or other hemorrhage
* renal failure (GFR\<60 ml/min/1.73m2)
* blood transfusion in the last 4 months
* administration of cortisone in the last month
* pregnancy
* mental impairment
* medical conditions which are contraindications to exercise testing, such as:
acute myocardial infarction (in the last 6 months)
unstable angina
left main coronary stenosis or its equivalent
syncope
symptomatic severe aortic stenosis or other moderate stenotic valvular disease
uncontrolled arrhythmias causing symptoms
acute pulmonary embolus or pulmonary infarction
thrombosis of lower extremities
suspected dissecting aneurysm
pulmonary oedema
room air desaturation at rest \<85%
severe untreated arterial hypertension at rest (\>200 mmHg systolic, \>120 mmHg diastolic)
high degree atrioventricular block
hypertrophic cardiomyopathy and
orthopedic impairment that compromises exercise performance
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