Evaluation of [18F] PBR06 and PET as a Marker of Inflammation in Subjects With Neurological Conditions

Inclusion Criteria

• •The following criteria will be met for inclusion of AD subjects in this study:
• •* The participant is 50 years or older.
• •* Written informed consent is obtained.
• •* Participants have a clinical diagnosis of probable Alzheimer's disease based on National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association (NINCDS/ADRDA) criteria.
• •* Clinical Dementia Rating Scale score ≤ 2.
• •* Modified Hachinski Ischemia Scale score of ≤ 4.
• •* For females, non-child bearing potential or a negative urine or blood pregnancy test on day of \[18F\]-PBR06 injection.
• •The following criteria will be met for inclusion of PD subjects in this study:
• •* The participant is 30 years or older.
• •* Written informed consent is obtained.
• •* Participants have a clinical diagnosis of Parkinson disease (at least two of the three cardinal symptoms: resting tremor, rigidity, bradykinesia).
• •* Hoehn and Yahr ≤4.
• •* For females, non-child bearing potential or a negative urine or blood pregnancy test on day of \[18F\]-PBR06 injection.
• •The following criteria will be met for inclusion of MS subjects in this study:
• •* The participant is 18 years or older.
• •* Written informed consent is obtained.
• •* Participants have a clinical diagnosis of Multiple Sclerosis (per the 2005 Revised McDonald Criteria; Polman, et al., 2005).
• •* Kurtzke Expanded Disability Status Scale (EDSS) ≤ 7.5.
• •* For females, non-child bearing potential or a negative urine or blood pregnancy test on day of \[18F\]-PBR06 injection
• •The following criteria will be met for inclusion of healthy control subjects in this study:
• •* The participant is 18 years or older.
• •* Written informed consent is obtained.
• •* Negative history of neurological or psychiatric illness based on evaluation by a research physician.
• •* Clinical Dementia Rating score = 0.
• •* For females, non-child bearing potential a negative urine or blood pregnancy test on day of \[18F\]-PBR06 injection.