Age

18–75

Sex

ALL

Healthy volunteers

Not accepted

Patients with histologically confirmed adenocarcinoma of the colon or rectum
Unresectable metastases
At least one bidimensionally measurable lesion of ≥ 1 cm
No previous chemotherapy for metastatic disease; Completed at least more than 1 year oxaliplatin therapy for adjuvant treatment
18-75 years old
ECOG 0-2
Life expectancy greater than 3 months
Hemogram: WBC≥4.0 X109/L, ANC ≥2 X109/L, PLT ≥100 X109/L, Hb ≥90g/L,
Adequate Renal Function
Adequate Liver Function
Signed informed consent before the treatment

Patients with previous oxaliplatin based adjuvant chemotherapy within 1 Year
Completely or partially bowel obstruction
Presence of peripheral neuropathy (CTC\>grade I)
Severe mental disorder
CNS metastasis
With other severe disease: uncontrolled active infectious disease, uncontrolled hypertension, heart infarction within 1 year, uncontrolled high-risk arrhythmia, unstable angina
With other malignant disease previously or concurrently
Receive other anti-tumor treatment
Pregnant or lactating women, or women of child bearing potential without contraceptive method.

OPTIMOX1 in Chinese mCRC Patients