Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Zurich
Not desired
Age
40–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Dyspnea at rest or at minimal physical activity, severe limitation of exercise capacity (6-min walk distance \< 350 m).
Acceptance of an increased perioperative mortality (approximately 2 %) and/or morbidity (long lasting hospitalization due to prolonged air leaks)
COPD (GOLD guidelines) with severe obstructive ventilatory defect (FEV1 \<35% predicted)
Functional aspects of lung emphysema, i.e. irreversible hyperinflation with a residual volume to total lung capacity ratio (RV/TLC) of \>0.65 and an impaired total lung diffusion capacity (DLCO), usually \< 40% predicted.
Pulmonary emphysema confirmed by high resolution computer tomography
You may not be if
Age \> 75years
"Vanishing" lung or diffuse lung emphysema on CT, FEV1 \<20% predicted and DLCO \<20% predicted, and hypercapnia (PaCO2 \>7.3kPa)
Overt active coronary artery disease, severe left ventricular function impairment
Pulmonary hypertension with a mean pulmonary artery pressure \>35 mmHg at rest
Acute bronchopulmonary infection, bronchiectasis on high resolution tomography
Pulmonary cachexia (body mass index \<18kg/m2)
Neoplastic disease with a life expectancy of less than 2 years
Addiction to alcohol/drugs
Relevant renal (creatinine \>150ug/ml), active gastroenterological (GI-bleeding in the previous year, abnormal liver function, active inflammatory bowel disease) or active neurological disease.
Clareo Health | Mechanisms of Vascular Damage in Patients With Chronic Obstructive Pulmonary Disease
