Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Abramson Cancer Center at Penn Medicine
Detailed Description
OBJECTIVES:
I. To determine the feasibility of using \[123-I\] ADAM Serotonin transporter (SERT) binding as a putative biomarker to visualize the mechanism of effects of acupuncture for hot flashes involving serotonin.
OUTLINE: Patients undergo acupuncture twice weekly for 2 weeks and then once weekly for 6 weeks. Patients undergo single photon emission computed tomography imaging with iodine 123-I ADAM before and after completion of acupuncture.
After completion of study treatment, patients are followed for 4 weeks.
Age
18–any
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
History of Stage I, II, or III breast cancer for at least 12 months
Have been seen by an oncologist within the previous 6-month period and determined to be free of disease by clinical examination and history
Have been receiving endocrine therapy (tamoxifen or aromatase inhibitors for at least four weeks)
Experienced hot flashes with a hot flash composite score of 5 or greater per day
Hot flashes have been present for at least a month before study entry
You may not be if
Currently on chemotherapy or radiation therapy as adjuvant treatment
Started with hormonal therapies such as tamoxifen or aromatase inhibitors within the last 4 weeks; or plan to change or terminate hormonal therapies in the next 14 weeks
Any history of use of psychotropic medication such as SSRI use for the past 6 months
Any past use of centrally acting medications such as clonidine for the past 6 months
Any past diagnosis of a Major Depressive Episode within the last 6 months
Any allergy to iodine or shell-fish or radio-nuclear materials
Current use of estrogen and/or progestin
Pregnancy
Breast feeding
Women of child-bearing potential NOT willing to use a medically acceptable form of contraception
Current use of any anti-convulsant such as gabapentin
History of cerebral infarction (including lacunar infarct with symptoms \>= 24 hours duration)
History of Binswanger's disease (or a history of hypertensive encephalopathy)
History of intracranial hemorrhage
History of head trauma with loss of consciousness
History of encephalitis
History of extended exposure to known neurotoxin (e.g., cyanide, carbon monoxide)
