Primary Operation in SYnchronous meTastasized InVasivE Breast Cancer

Inclusion Criteria

• •Patients age ≥ 18 years
• •Eastern Cooperative Oncology Group Performance Status is 0 -2
• •Untreated synchronous metastasized invasive carcinoma of the breast with the primary tumor in situ (bilateral synchronous metastasized breast cancer patients are eligible)
• •The primary tumor must be identified and may be any size, however, primary resection with resection free margins must be possible
• •Invasive adenocarcinoma of the breast on histological examination
• •The metastatic site must be identified by radiological assessment(Computer Tomography of the chest and the abdomen OR ultrasound and chest x ray for visceral metastases; bone scan AND/OR computer tomography AND/OR magnetic resonance for bone metastases). A biopsy is not necessary.
• •Written informed consent must be obtained and documented prior to beginning any protocol specific procedures and according to local regulatory requirements
• •able to comply with the protocol requirements during the treatment and follow-up period.