A Pilot Double-blind Sham-controlled Trial of Repetitive Transcranial Magnetic Stimulation for Patients With Refractory Schizophrenia Treated With Clozapine
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Lead
Hospital de Clinicas de Porto Alegre
Seventeen patients with DSM-IV TR diagnosis of schizophrenia were randomized in two groups. First group received 20 sessions of 20 minutes each of low-frequency (1Hz) rTMS applied over the left temporoparietal cortex (LTPC).
Second group received sham (placebo) stimulation over the LTPC for the same period of time. All patients were considered as having refractory schizophrenia and in use of at least 400mg/day of clozapine and refering auditory hallucinations occuring at least 5 times a day.
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients with DSM IV TR diagnose of schizophrenia with treatment-resistant auditory hallucinations.
Use of at least 400mg/day of clozapine
Men and women from 18 to 65 years old
Fertile women must be using adequate contraceptive method
BPRS score of at least 27
You may not be if
Suicide risk
Patients with epilepsy, brain surgery and/or head trauma in the past, use of cardiac pace maker or metalic clip in the head
Diagnose of substance abuse/dependance
Severe uncontrolled organic disease that may interfere in the patient´s participation in the study
Any other reason that, in the investigator´s opinion, might interfere with the patient´s participation in the study, such as non compliance.
Clareo Health | A Pilot Double-blind Sham-controlled Trial of Repetitive Transcranial Magnetic Stimulation for Patients With Refractory Schizophrenia Treated With Clozapine
