Preoperative Accelerated Partial Breast Irradiation (APBI) for Women With Stage I and Select IIA Breast Cancer

Exclusion Criteria

• •1. Evidence of suspicious microcalcifications which are separate from the known lesion unless pathologically confirmed to be benign.
• •2. Patient with distant metastases.
• •3. Patients with invasive lobular or extensive in-situ lobular carcinoma or pure ductal carcinoma in-situ or non-epithelial breast malignancies such as sarcoma or lymphoma.
• •4. Patients with proven multicentric carcinoma (tumors in different quadrants of the breast or tumor separated by at least 4 cm) or with other clinically or radiographically suspicious areas in the ipsilateral breast unless confirmed to be negative for malignancy by biopsy.
• •5. Patient whose tumor is not visible on radiation treatment planning CT scan
• •6. Palpable or radiographically suspicious ipsilateral axillary, supraclavicular, infraclavicular or internal mammary nodes, unless there is histologic confirmation that these nodes are negative for tumor.
• •7. Prior hormonal or non-hormonal therapy or radiation therapy for the current breast cancer.
• •8. Patients with Paget's disease of the nipple.
• •9. Patients with skin involvement, regardless of tumor size.
• •10. Patients with a breast technically unsatisfactory for radiation therapy.
• •11. Patients with collagenous diseases, specifically systemic lupus erythematosis, scleroderma, or dermatomyositis.
• •12. Patients with co-existing medical conditions with life expectancy less than 2 years.
• •13. Patients with psychiatric or addictive disorders that would preclude obtaining informed consent.
• •14. Patients who are pregnant or lactating due to potential exposure of the fetus to RT and unknown effects of RT to lactating females.