Significant risk of suicide

History of mania, bipolar disorder, psychotic disorder, schizophrenia, or a current episode of major depressive disorder

Myocardial infarction and/or stroke within the prior 12 months

Mean systolic blood pressure \> 180 mm Hg or mean diastolic blood pressure \> 110 mm Hg at Screening (Visit 1)

Active liver disease

Severe renal impairment

Platelet and bleeding disorders

Female patients who are pregnant or breastfeeding

Discontinuation Study of the Durability of Effect of Milnacipran for the Treatment of Fibromyalgia