1. SLE patients who are allergic to doxycycline or other tetracyclines.

2. Patients who are pregnant or are planning to become pregnant.

3. Patients who are on oral contraceptives (any method of contraception other than OCPs can be used.

4. Tetracycline use within the previous 2 weeks of enrollment.

5. Patients who are currently on statins will be excluded, because statins might reduce hs- CRP.

6. Patients who are on warfarin.

7. Patients whose most recent EKG shows significant cardiac dysrhythmias or heart block.

Doxycycline Outcomes in Lupus Erythematosus