Alfentanil: Simultaneous Testing Pilot

Exclusion Criteria

• •Known history of liver or kidney disease
• •Use of prescription or non prescription medications, herbals or foods known to be metabolized by or affect CYP3A (including oral birth control medications)
• •Females who are pregnant or nursing
• •Known history of drug or alcohol addiction (prior or present addiction or treatment for addiction)
• •Direct physical access to and routine handling of addicting drugs in the regular course of duty (this is a routine exclusion from studies of drugs with addiction potential).
• •History of bradycardia
• •Respiratory rate \<10
• •History of significant pulmonary disease
• •History of pre-existing medical condition predisposing to respiratory depression
• •Systolic blood pressure \<100 mgHg and diastolic blood pressure \<70mmHg