Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Biogen
Age
18–any
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Age 18 years of age
Must have histologically or cytologically confirmed estrogen receptor- positive or progesterone receptor-positive, incurable, locally advanced, or metastatic breast cancer.
Must have disease progression during treatment with a nonsteroidal AI for locally advanced or metastatic disease, or relapse during treatment or within 12 months of discontinuation of treatment in the adjuvant setting.
Must be a postmenopausal female.
Must have measurable or evaluable disease.
* Measurable disease is defined as \>=1 lesion with a diameter of \>=10 mm
* Evaluable disease is defined as bone lesions evaluable by plain X ray, CT scan, or MRI. Lesions identified only by radionuclide bone scan are not allowed.
One prior chemotherapy regimen for advanced mBC is allowed.
Prior radiotherapy is allowed.
Must be able to swallow and retain oral medication.
ECOG performance status of \<=2
Required laboratory values
* Plasma cortisol and adrenocorticotropic hormone (ACTH) levels that are not suggestive of adrenal insufficiency unless on replacement therapy for known adrenal insufficiency.
You may not be if
HER2 overexpressing tumor.
History of central nervous system (CNS) metastasis.
Previous treatment with exemestane or treatment with an Hsp90 inhibitor.
Use of proton pump inhibitors.
Known history of or positive test result for hepatitis B or C or HIV.
History of gastrectomy or major surgery to small intestine.
