Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Royal Marsden NHS Foundation Trust
To establish whether or not the prone (face down) position reduces exposure of healthy tissue to radiation when compared to the supine position. To compare patient comfort and acceptability in each of the prone and supine positions. To perform a time and motion study for radiotherapy planned and delivered in each of the prone and supine positions.
Age
18–any
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Complete microscopic excision of early stage invasive ductal or lobular carcinoma (pT1-3b N0-1 M0) with breast preservation.
Paired titanium clips marking anterior, posterior, and radial walls of excision cavity
Breast cup size C or above
Recommendation for whole breast radiotherapy
No requirement for nodal irradiation
Ability to lie prone on breast board
For left-sided breast cancer patients, cardiac and LAD doses must be ≤10% greater than those predicted for the supine position.
For all patients, the following absolute dose constraints should be met: ≤5% of heart volume to receive 18Gy and ≤10% of ipsilateral lung volume to receive ≥20Gy
Age ≥18
PS ≤1
No previous radiotherapy to the affected breast
No concomitant herceptin
Absence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule.
Written informed consent given according to ICH/GCP before registration/ randomisation.
Patients can only be randomised into this trial once.
