Albumin for Intracerebral Hemorrhage Intervention

Exclusion Criteria

• •ICH volume \< 5 cc
• •Glasgow Coma Scale \< 6
• •Surgical evacuation anticipated
• •Pre-existing medical, neurological or psychiatric disease that would confound the neurological, functional, or imaging evaluations
• •Pregnancy or breastfeeding
• •Hemodynamic instability (SBP \< 100 mmHg, \> 200 mmHg)
• •Current participation in another experimental treatment protocol
• •Renal impairment with GFR \< 30 or Creatinine \> 2.0
• •History of or known allergy to albumin
• •History of or known severe allergy to rubber latex
• •Episode/exacerbation of congestive heart failure (CHF) from any cause in the last 6 months. (An episode of congestive heart failure is any heart failure that required a change in medication, diet or hospitalization)
• •Acute myocardial infarction in the last 6 months
• •Elevated serum troponin level on admission \> 0.1 mcg/L
• •Known valvular heart disease with CHF in the last 6 months
• •Known (or in the investigator's judgment) existence of severe aortic stenosis or mitral stenosis
• •Cardiac surgery involving thoracotomy (e.g., coronary artery bypass graft (CABG), valve replacement surgery) in the last 6 months
• •Suspicion of aortic dissection on admission
• •Acute arrhythmia (including any tachy- or bradycardia) with hemodynamic instability on admission (systolic blood pressure \< 100 mmHg).
• •Findings on physical examination of any of the following: (1) jugular venous distention (JVP \> 4 cm above the sternal angle); (2) 3rd heart sound; (3) resting tachycardia (heart rate \> 100/min) attributable to congestive heart failure; (4) abnormal hepatojugular reflux; (5) lower extremity pitting edema attributable to congestive heart failure or without apparent cause; (6) bilateral rales; and/or (7) if a chest x-ray is performed, definite evidence of pulmonary edema, bilateral pleural effusion, or pulmonary vascular redistribution.
• •Current acute or chronic lung disease requiring supplemental chronic or intermittent oxygen therapy.
• •Prosthetic heart valves
• •Contraindication to MRI (metal implant, etc.)
• •Documented left ventricular ejection fraction \< 35%