High-Intensity Focused Ultrasound Focal Ablation in Treating Patients With Progressive Prostate Cancer

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically confirmed prostate cancer by transrectal or transperineal template prostate biopsies
• * Stage ≤ T3bN0M0
• * Gleason grade ≤ 8
• * Serum PSA ≤ 20 ng/mL
• * Bone scan- or cross-sectional imaging-negative for metastatic or nodal (outside prostate) disease
• * No metastatic disease and/or nodal spread by CT scan or MRI
• Index lesion or other secondary lesions with a volume ≥ 0.5 cc by MRI
• No prostatic calcification and cysts (on transrectal ultrasound) that would interfere with effective delivery of therapy
• PATIENT CHARACTERISTICS:
• Able to tolerate a transrectal ultrasound
• Not allergic to latex
• Fit for major surgery as assessed by a consultant anaesthetist
• Able to have MRI scanning (i.e., none of the following conditions: severe claustrophobia, permanent cardiac pacemaker, metallic implant, etc.)
• PRIOR CONCURRENT THERAPY:
• No prior radiotherapy
• No androgen suppression and/or hormone treatment within the past 12 months
• No prior significant rectal surgery preventing insertion of transrectal high-intensity focused ultrasound (HIFU) probe (decided on the type of surgery in individual cases)
• No prior transurethral resection of the prostate (or equivalent procedures) within the past 2 years
• No prior HIFU, cryosurgery, thermal, or microwave therapy to the prostate